Acute promyelocytic leukemia and variant fusion proteins: PLZF-RARα fusion protein at a glance.

  title={Acute promyelocytic leukemia and variant fusion proteins: PLZF-RAR$\alpha$ fusion protein at a glance.},
  author={Liaqat Hussain and Yasen Maimaitiyiming and Khairul Islam and Hua Naranmandura},
  journal={Seminars in oncology},
Classical acute promyelocytic leukemia (APL) cases are associated with the promyelocytic leukemia-retinoic acid receptor α (PML-RARα) chimeric fusion protein. Almost all the variant chimeric proteins share the same RARα component. Currently, more than 11 fusion partners of RARα have been identified, of which PML accounts for 95%, promyelocytic leukemia zinc finger (PLZF) take up2%, and the remaining are other variants. Although all-trans retinoic acid and arsenic trioxide have shown remarkable… Expand
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The RARα-PLZF chimera associated with Acute Promyelocytic Leukemia has retained a sequence-specific DNA-binding domain
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