Acute progesterone can recruit sex-specific neurochemical mechanisms mediating swim stress-induced and kappa-opioid analgesia in mice.

@article{Sternberg2004AcutePC,
  title={Acute progesterone can recruit sex-specific neurochemical mechanisms mediating swim stress-induced and kappa-opioid analgesia in mice.},
  author={Wendy F. Sternberg and Elissa J. Chesler and Sonya G. Wilson and Jeffrey S Mogil},
  journal={Hormones and behavior},
  year={2004},
  volume={46 4},
  pages={467-73}
}
There is a qualitative sex difference in the neurochemical mediation of stress-induced and kappa-opioid analgesia; these phenomena are dependent on N-methyl-d-aspartic acid (NMDA) receptors in males but not females. Progesterone modulation of this sex difference was examined in mice. Analgesia against thermal nociception was produced by forced cold water swim or by systemic administration of the kappa-opioid agonist, U50,488. As seen previously, the NMDA receptor antagonist MK-801 blocked both… CONTINUE READING

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