Acute profound sensorineural hearing loss as the initial manifestation of Hairy Cell Leukemia, Case Report and literature review

  title={Acute profound sensorineural hearing loss as the initial manifestation of Hairy Cell Leukemia, Case Report and literature review},
  author={Abdulaziz Alenazi and Riyadh Alhedaithy and A. Alfayez and Yazeed Alghonaim},
  journal={International Journal of Surgery Case Reports},
  pages={200 - 203}
Highlights • Hematologic diseases rarely present with sudden hearing lossas an initial symptom.• There are few cases reported the association of hematology disorder with (SSNHL).• This article represents the first reported case of Hairy cell leukemia (HCL), which presented with acute unilateral sudden profound sensorineural hearing loss (SSNHL) as an inital manifestation. 
1 Citations
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Bilateral sudden profound SNHL and vestibular hypofunction is a presenting symptom of hyperviscosity syndrome in hematologic malignancy, and cases with profound hearing loss are unlikely to recover serviceable hearing. Expand


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A 50-year-old male with CML whose first signs and symptoms were unilateral sudden hearing loss and tinnitus in the right ear, vertigo and nausea was presented and aetiopathogenetic mechanisms, clinical and radiological aspects and therapeutic options were discussed. Expand
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A case with an initial presentation of sudden onset profound bilateral sensorineural hearing loss is described and the underlying pathology was found to be an occult breast carcinoma, a previously unreported finding. Expand
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Both leucophoresis and high dose chemotherapy capable of rapid cytoreduction are recommended in patients with chronic myeloid leukaemia with profound hearing loss, as conventional chemotherapy is rarely followed by recovery. Expand
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The hypothesis is put forth that idiopathic sudden sensorineural hearing loss may be the result of pathologic activation of cellular stress pathways involving nuclear factor-κB within the cochlea. Expand
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Hairy cell leukemia (HCL) and HCL‐like disorders, including HCL variant (HCL‐V) and splenic diffuse red pulp lymphoma (SDRPL), are a very heterogeneous group of mature lymphoid B‐cell disorders,Expand
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The occurrence of decompensated metabolic and cardiovascular diseases and the possibility of first manifestation of auto-immune disease and cerebello-pontine angle tumors justify an adequate protocol for investigation of SSNHL. Expand