Acute pretranslational regulation of type III iodothyronine deiodinase by growth hormone and dexamethasone in chicken embryos.

@article{Geyten1999AcutePR,
  title={Acute pretranslational regulation of type III iodothyronine deiodinase by growth hormone and dexamethasone in chicken embryos.},
  author={Serge van der Geyten and Nadine Buys and J P Sanders and Eddy M-P Decuypere and Theo J. Visser and Eduard R. K{\"u}hn and Veerle M. Darras},
  journal={Molecular and cellular endocrinology},
  year={1999},
  volume={147 1-2},
  pages={49-56}
}
Both growth hormone (GH) and glucocorticoids are regulators of thyroid hormone metabolism in vertebrates. Studies on chicken embryos demonstrated that intravenous (i.v.) injection of chicken GH or glucocorticoids results in increased plasma 3,3',5-triiodothyronine (T3) concentrations, and this through a reduction of hepatic type III iodothyronine deiodinase (D3) activity. The recent cloning of chicken type I iodothyronine deiodinase (D1) and D3 offers the tools to investigate at what level (pre… CONTINUE READING
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