Acute poisoning with gold cyanide

@article{Wright1986AcutePW,
  title={Acute poisoning with gold cyanide},
  author={Ian H. Wright and C. J. Vesey},
  journal={Anaesthesia},
  year={1986},
  volume={41}
}
A case of deliberate ingest ion of an electroplating solution containing gold cyanide is described. Despite the use of an antidote, and supportive treatment for cyanide poisoning, the patient died after 13 hours. Sublethal cyanide and high red blood cell gold levels suggest acute gold toxicity as the most likely cause of death. Evidence for this is discussed and recommendations are made for the treatment of cyanide poisoning. 
Fatality from potassium gold cyanide poisoning
TLDR
An 84-year-old man who presented after an intentional ingestion of 0.5–1 teaspoons of potassium gold cyanide rapidly developed severe lactic acidosis, multiorgan dysfunction and ultimately expired.
An incident of hydrogen cyanide poisoning.
  • K. Lam, F. Lau
  • Chemistry
    The American journal of emergency medicine
  • 2000
The biohazard potential of cyanide poisoning during postmortem examination.
TLDR
It was found that potentially toxic concentrations of cyanide can develop in personnel so exposed to any significant degree of biohazard from cyanide remaining in body cavities or tissues of the decedent or both.
Poisonings in laboratory personnel and health care professionals.
The efficacy and adverse effects of dicobalt edetate in cyanide poisoning
TLDR
Dicobalt edetate is an effective cyanide antidote when given to patients with systemic cyanide poisoning, but it has the potential to give rise to adverse reactions, particularly when administered in the absence of intoxication.
Antidotes and Treatments for Chemical Warfare/Terrorism Agents: An Evidence‐Based Review
TLDR
The evidence supporting the efficacy of antidotes used or recommended for the potential chemical warfare agents of most concern is reviewed, highlighting the need for additional research in this area.
The di(thiourea)gold(I) complex [Au{S=C(NH2)2}2][SO3Me] as a precursor for the convenient preparation of gold nanoparticles
Abstract The synthesis of [Au{S=C(NH2)2}2][SO3Me] (1) (a) by the anodic oxidation of gold metal in an anolyte of thiourea and methansulfonic acid and (b) by the reaction of Au(OH)3 with an aqueous
GOLD AND NANO-GOLD IN MEDICINE: OVERVIEW, TOXICOLOGY AND PERSPECTIVES
TLDR
The review particularly deals with the use of GNPs and bio-conjugated GNPs in cancer treatment, drug or gene delivery, DNA detection, biomedical imaging, and also the toxicity of gold and GNPs.
...
...

References

SHOWING 1-10 OF 32 REFERENCES
The treatment of cyanide poisoning in children.
The widely published schedule for the treatment of cyanide poisoning by the nitrite thiosulfate method of Chen is based on adult work and is potentially lethal for children under 25 kg in weight.
Hydrogen cyanide poisoning: treatment with cobalt EDTA.
TLDR
It is concluded that, because of the degree of patient symptomatology associated from the use of cobalt EDTA, this therapy be reserved only for patients with the most severe degress of exposure to CN, and that in all other cases combined sodium nitrite and sodium thiosulphate therapy should be employed.
The use of dicobalt edetate (Kelocyanor) in cyanide poisoning
A case of accidental poisoning with sodium cyanide is reported. The patient was treated with a new antidote, dicobalt edetate (Kelocyanor). Blood levels of cyanide were shown to fall markedly.
The importance of oxygen in the treatment of cyanide poisoning.
TLDR
Oxygen, sodium nitrite, and thiosulfate in combination are believed to represent the best present-day therapy of cyanide intoxication.
Acute cyanide poisoning complicated by lactic acidosis and pulmonary edema.
TLDR
A review of the literature shows that many case reports are poorly documented and do not provide a firm basis for evaluating therapy, and in the absence of a suitable history, diagnosis of cyanide poisoning is difficult.
Cyanide and thiocyanate concentrations following sodium nitroprusside infusion in man.
TLDR
It is believed that the development of metabolic acidosis, and the recent fatalities involving SNP, are attributable to histotoxic hypoxia as a result of excessive plasma concentrations of cyanide.
The Antidotal Action of Thiosulfate Following Acute Nitroprusside Infusion in Dogs
TLDR
The results suggest that thiosulfate alone is a sufficient antidote for cyanide toxicity arising from excessive SNP administration and suggest that red blood cells may be involved in the detoxication process.
Cyanide toxicity after immersion and the hazards of dicobalt edetate.
TLDR
Apres immersion totale pendant 3 mn dans le cyanure de cuivre, le malade est inconscient, cyanose et respire irregulierement, puis a 2 reprises 300 mg de l'antidote: edetate de cobalt.
Effect of sodium thiosulfate on cis-dichlorodiammineplatinum(II) toxicity and antitumor activity in L1210 leukemia.
TLDR
Sodium thiosulfate offers the possibility of systemic protection against the cytotoxicity of regionally administered DDP in man and partially reduced the antitumor activity of DDP.
...
...