Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice.

@article{Whalen2008AcutePP,
  title={Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice.},
  author={Michael Whalen and Turgay Dalkara and Zerong You and Jian-hua Qiu and Daniela Bermpohl and Niyati Mehta and Bernhard Suter and Pradeep G Bhide and Eng H. Lo and Maria Ericsson and Michael A. Moskowitz},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2008},
  volume={28 3},
  pages={490-505}
}
Cell death after traumatic brain injury (TBI) evolves over days to weeks. Despite advances in understanding biochemical mechanisms that contribute to posttraumatic brain cell death, the time course of cell injury, death, and removal remains incompletely characterized in experimental TBI models. In a mouse controlled cortical impact (CCI) model, plasmalemma permeability to propidium iodide (PI) was an early and persistent feature of posttraumatic cellular injury in cortex and hippocampus. In… CONTINUE READING

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