Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity.

@article{Mandolesi2004AcutePR,
  title={Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity.},
  author={Georgia Mandolesi and Federico Madeddu and Yuri Bozzi and Lamberto Maffei and Gian Michele Ratto},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 15},
  pages={1934-6}
}
The transection of the axon of central neurons has dramatic consequences on the damaged cells and nerves. Injury activates molecular programs leading to a complex repertoire of responses that, depending on the cellular context, include activation of sprouting, axonal degeneration, and cell death. Although the cellular mechanisms started at the time of lesion are likely to shape the changes affecting injured cells, the acute physiological reaction to trauma of mammalian central neurons is not… CONTINUE READING

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