Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan in patients with colorectal liver metastases.

Abstract

BACKGROUND In this study, we have evaluated hepatotoxicity, secondary cytokine production and hepatic acute-phase response (APR) in patients who underwent isolated hepatic perfusion (IHP) with tumour necrosis factor (TNF) alpha and melphalan for irresectable colorectal liver metastases. DESIGN An extracorporeal veno-venous bypass was used to shunt blood… (More)

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Cite this paper

@article{Vries1999AcutephaseRP, title={Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan in patients with colorectal liver metastases.}, author={Margreet R de Vries and Inne H. M. Borel Rinkes and Antonius J G Swaak and Cornelis Erik Hack and C. J. van de Velde and Theo Wiggers and Robert A. E. M. Tollenaar and Peter JK Kuppen Kuppen and Alexis Eggermont}, journal={European journal of clinical investigation}, year={1999}, volume={29 6}, pages={553-60} }