Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.

@article{Hattori1990AcutephaseRI,
  title={Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.},
  author={Masakazu Hattori and Lawrence J. Abraham and Wolfgang Northemann and Georg H. Fey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 6},
  pages={2364-8}
}
Interleukin 6 (IL-6) was established as a transcriptional inducer of the rat alpha 2-macroglobulin gene, a prototype liver acute-phase gene. Maximum induction occurred when the 5' flanking sequences of this gene (position -209 to -43) directed expression from the gene's own TATA box and transcription start site. Removal of the hexanucleotide CTGGGA (position -164 to -159) abolished 60-70% of the hormonal induction in FAO1 rat hepatoma cells. This hexanucleotide was defined as the IL-6 response… CONTINUE READING

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