Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects.

@article{Vestergaard2013AcutePT,
  title={Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects.},
  author={Esben Thyssen Vestergaard and Niels M\oller and Jens Otto Lunde J\orgensen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={304 12},
  pages={E1273-80}
}
Ghrelin is a gut-derived peptide and an endogenous ligand for the ghrelin receptor. Intravenous infusion of ghrelin induces insulin resistance and hyperglycemia and increases circulating levels of nonesterified free fatty acids. Our objective was to investigate whether the metabolic effects are mediated directly by ghrelin in skeletal muscle and adipose (peripheral and central) tissues. Ten healthy men (24.9 ± 1.3 yr) received 300 min of supraphysiological ghrelin administration by… CONTINUE READING

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