Acute pandysautonomia: mass spectrometric and histopathological studies of the sympathetic nervous system during long term L-threo-3,4-dihydroxyphenylserine treatment.

  • M Ushiyama, S Ikeda, T Suzuki, M Yazawa, N Yanagisawa, S Tsujino
  • Published 1996 in
    Journal of neurology, neurosurgery, and…

Abstract

Stable isotope labelled L-threo-3,4-dihydroxyphenylserine (L-DOPS) infusion tests and histopathological studies of the rectal autonomic nerves were performed in a patient with acute pandysautonomia. A pronounced increase in blood pressure occurred and stable isotope labelled noradrenaline appeared in the plasma during L-DOPS infusion in the acute stage, but decreased during the next three years. Noradrenergic nerve fibres in the rectal mucosa showed no recovery, and so clinical improvement had occurred without apparent significant regeneration of the peripheral autonomic nerves.

Cite this paper

@article{Ushiyama1996AcutePM, title={Acute pandysautonomia: mass spectrometric and histopathological studies of the sympathetic nervous system during long term L-threo-3,4-dihydroxyphenylserine treatment.}, author={M Ushiyama and S Ikeda and T Suzuki and M Yazawa and N Yanagisawa and S Tsujino}, journal={Journal of neurology, neurosurgery, and psychiatry}, year={1996}, volume={61 1}, pages={99-102} }