Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.

@article{Winston2003AcutePR,
  title={Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.},
  author={J H Winston and Hiroki Toma and Mohan Shenoy and Zhi-jun He and Lei Zou and Shu-yuan Xiao and M. Micci and Pankaj Jay Pasricha},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2003},
  volume={4 6},
  pages={
          329-37
        }
}
Although pain is a cardinal feature of pancreatitis, its pathogenesis is poorly understood and treatment remains difficult. Nociceptive sensitization in several somatic pain models has been associated with activation of protein kinases including trkA, protein kinase C, and protein kinase A. We therefore tested the hypothesis that systemic treatment with a kinase inhibitor, k252a, known to inhibit all of these kinases would alleviate pain in an animal model of pancreatitis. Von Frey filament… CONTINUE READING

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