Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras.

@article{Carrire2009AcutePM,
  title={Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras.},
  author={Catherine Carri{\`e}re and Alison L. Young and Jason R. Gunn and Daniel S. Longnecker and Murray Korc},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={382 3},
  pages={561-5}
}
Chronic pancreatitis increases by 16-fold the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. It also appears to accelerate cancer progression in genetically engineered mouse models. We now report that in a mouse model where oncogenic Kras is activated in all pancreatic cell types, two brief episodes of acute pancreatitis caused rapid PanIN progression and accelerated pancreatic cancer development. Thus, a brief inflammatory insult to the pancreas… CONTINUE READING

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