Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during sevoflurane sedation.

@article{Sarton1996AcutePA,
  title={Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during sevoflurane sedation.},
  author={Elise Y Sarton and Albert Dahan and Luc J Teppema and Maarten Jlj van den Elsen and Erik Olofsen and Adriaan Berkenbosch and Jack W van Kleef},
  journal={Anesthesiology},
  year={1996},
  volume={85 2},
  pages={295-303}
}
BACKGROUND To quantify the effects of acute pain on ventilatory control in the awake and sedated human volunteer, the acute hypoxic ventilatory response was studied in the absence and presence of noxious stimulation before and during 0.1 minimum alveolar concentration sevoflurane inhalation. METHODS Step decreases in end-tidal partial pressure of oxygen from normoxia into hypoxia (approximately 50 mmHg) were performed in 11 healthy volunteers. Four acute hypoxic ventilatory responses were… CONTINUE READING