Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.

@article{Berdichevsky2010AcuteOS,
  title={Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.},
  author={Alina Berdichevsky and Leonard P. Guarente and Avirup Bose},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 28},
  pages={21581-9}
}
Chronic oxidative stress results in decreased responsiveness to insulin, eventually leading to diabetes and cardiovascular disease. Activation of the JNK signaling pathway can mediate many of the effects of stress on insulin resistance through inhibitory phosphorylation of insulin receptor substrate 1. By contrast, exercise, which acutely increases oxidative stress in the muscle, improves insulin sensitivity and glucose tolerance in patients with Type 2 diabetes. To elucidate the mechanism… CONTINUE READING

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Oxidative Stress, JNK Localization, and Insulin

J. P. McClung, C. A. Roneker, +4 authors X. G. Lei
Proc. Natl. Acad. Sci. U.S.A. 101, • 2004

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