Acute oral metformin enhances satiation and activates brainstem nesfatinergic neurons.

@article{Rouquet2014AcuteOM,
  title={Acute oral metformin enhances satiation and activates brainstem nesfatinergic neurons.},
  author={Tha{\"i}s Rouquet and Pierre Cl{\'e}ment and St{\'e}phanie Gaig{\'e} and Catherine Tardivel and Julien Roux and Michel Dallaporta and Bruno Bariohay and J. P. Troadec and Bruno Lebrun},
  journal={Obesity},
  year={2014},
  volume={22 12},
  pages={2552-62}
}
OBJECTIVE The study was designed to determine metformin effects on meal pattern, gastric emptying, energy expenditure, and to identify metformin-sensitive neurons and their phenotype. METHODS This study was performed on C57BL/6J and obese/diabetic (db/db) mice. Metformin (300 mg/kg) was administered by oral gavage. Food intake, meal pattern, oxygen… CONTINUE READING