Acute opioid dependence in the cardiovascular system of the spinal rat.

@article{Cruz1993AcuteOD,
  title={Acute opioid dependence in the cardiovascular system of the spinal rat.},
  author={Silvia Lorenia Cruz and Jul{\'i}an E. Villarreal},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 1},
  pages={128-33}
}
This article analyzes and characterizes the early development of opioid dependence in the cardiovascular system of the spinal rat. The main part of the study deals with changes in mean arterial pressure and heart rate induced by naloxone (NLX) in spinal rats pretreated with single doses of morphine. The results show that the cardiovascular system of the spinal rat is highly sensitive to the abstinence-precipitating actions of NLX after a single dose of morphine. Dose-response curves for… CONTINUE READING

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