Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions.

@article{Laleman2011AcuteonchronicLF,
  title={Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions.},
  author={Wim Laleman and Len Verbeke and Philippe Meersseman and Joost Wauters and Jos van Pelt and David Cassiman and Alexander Wilmer and Chris Verslype and Frederik Nevens},
  journal={Expert review of gastroenterology & hepatology},
  year={2011},
  volume={5 4},
  pages={523-37; quiz 537}
}
In recent years, acute-on-chronic liver failure has been recognized as a specific clinical form of liver failure associated with cirrhosis. The syndrome refers to an acute deterioration of liver function and subsequently of other end organs over a period of weeks following a precipitating event in a patient with previously well- or reasonably well-compensated cirrhosis. These precipitating events include either an indirect (e.g., variceal hemorrhage, sepsis) or a direct (e.g., drug-induced… CONTINUE READING