Acute-on-Chronic Liver Failure: Pathophysiological Basis of Therapeutic Options

@article{Jalan2002AcuteonChronicLF,
  title={Acute-on-Chronic Liver Failure: Pathophysiological Basis of Therapeutic Options},
  author={Rajiv Jalan and Roger Williams},
  journal={Blood Purification},
  year={2002},
  volume={20},
  pages={252 - 261}
}
The vast majority of patients that are referred to a specialist hepatological centre suffer from acute deterioration of their chronic liver disease. Yet, this entity of acute-on-chronic liver failure remains poorly defined. With the emergence of newer liver support strategies, it has become necessary to define this entity, its pathophysiology and the short- and long-term prognosis. This review focusses upon how a precipitant such as an episode of gastrointestinal bleeding or sepsis may start a… 
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