Acute neuroactive drug exposures alter locomotor activity in larval zebrafish.

@article{Irons2010AcuteND,
  title={Acute neuroactive drug exposures alter locomotor activity in larval zebrafish.},
  author={Tom Irons and Robert C. Macphail and Deborah L. Hunter and S. J. Padilla},
  journal={Neurotoxicology and teratology},
  year={2010},
  volume={32 1},
  pages={84-90}
}
As part of the development of a rapid in vivo screen for prioritization of toxic chemicals, we have begun to characterize the locomotor activity of zebrafish (Danio rerio) larvae by assessing the acute effects of prototypic drugs that act on the central nervous system. Initially, we chose ethanol, d-amphetamine, and cocaine, which are known, in mammals, to… CONTINUE READING