Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry

@article{Baer1998AcuteML,
  title={Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry},
  author={M R Baer and C Stewart and Dawn Lawrence and D E Arthur and Krzysztof Mr{\'o}zek and MP Strout and F P Davey and C F Schiffer and C Bloomfield},
  journal={Leukemia},
  year={1998},
  volume={12},
  pages={317-325}
}
11q23 translocations (t(11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL). Mixed lineage antigen expression has been reported in these leukemias, but its frequency and clinical significance are unknown. We immunophenotyped leukemia cells from 19 adult de novo AML patients with t(11q23) by multiparameter flow cytometry. Translocations included t(6;11)(q27;q23), t(9;11) (p22;q23), t(9;11;19… CONTINUE READING