Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation.

@article{Griffiths2010AcuteML,
  title={Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation.},
  author={Elizabeth A. Griffiths and Steven D Gore and Craig M. Hooker and Michael A. McDevitt and Judith E. Karp and Bruce D. Smith and Helai P. Mohammad and Ying Ye and James G. Herman and Hetty E. Carraway},
  journal={Leukemia & lymphoma},
  year={2010},
  volume={51 9},
  pages={1711-9}
}
Nuclear localization of non-phosphorylated, active beta-catenin is a measure of Wnt pathway activation and is associated with adverse outcome in patients with acute myeloid leukemia (AML). While genetic alterations of the Wnt pathway are infrequent in AML, inhibitors of this pathway are silenced by promoter methylation in other malignanices. Leukemia cell lines were examined for Wnt pathway inhibitor methylation and total beta-catenin levels, and had frequent methylation of Wnt inhibitors and… CONTINUE READING

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