Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group.

@article{Tarlock2014AcuteML,
  title={Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group.},
  author={Katherine G Tarlock and Todd A Alonzo and Pilar Palomo Moraleda and Robert B. Gerbing and Susana C. Raimondi and Betsy Hirsch and Yaddanapudi Ravindranath and Beverly J. Lange and William G A Woods and Alan S Gamis and Soheil Meshinchi},
  journal={British journal of haematology},
  year={2014},
  volume={166 2},
  pages={254-259}
}
Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and… CONTINUE READING

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