Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis

@article{Murugan2022AcuteMD,
  title={Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis},
  author={Nirosha J Murugan and Hannah J Vigran and Kelsie A. Miller and Annie Golding and Quang L Pham and Megan M. Sperry and Cody Rasmussen-Ivey and Anna Kane and David L. Kaplan and Michael Levin},
  journal={Science Advances},
  year={2022},
  volume={8}
}
Limb regeneration is a frontier in biomedical science. Identifying triggers of innate morphogenetic responses in vivo to induce the growth of healthy patterned tissue would address the needs of millions of patients, from diabetics to victims of trauma. Organisms such as Xenopus laevis—whose limited regenerative capacities in adulthood mirror those of humans—are important models with which to test interventions that can restore form and function. Here, we demonstrate long-term (18 months… 

Cellular responses in the FGF10‐mediated improvement of hindlimb regenerative capacity in Xenopus laevis revealed by single‐cell transcriptomics

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