Acute mitochondrial actions of glitazones on the liver: a crucial parameter for their antidiabetic properties.

@article{Sanz2011AcuteMA,
  title={Acute mitochondrial actions of glitazones on the liver: a crucial parameter for their antidiabetic properties.},
  author={M Sanz and Carlos S{\'a}nchez-Mart{\'i}n and Dominique Detaille and Guillaume Vial and Michel Rigoulet and Mohammed-Yehia El-Mir and Gloria Rodr{\'i}guez-Villanueva},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2011},
  volume={28 5},
  pages={899-910}
}
BACKGROUND/AIMS Glitazones are synthetic insulin-sensitizing drugs which act as agonists of peroxisome proliferator-activated receptor gamma (PPARγ). However, TZDs action does not exclude independent PPARγ-activation effects. Remarkably, direct mitochondrial action of these agents has not been fully studied yet. METHODS Oxygen consumption rates (JO(2)) were measured using a Clark-type oxygen electrode in intact hepatocytes and isolated liver mitochondria. Mitochondrial reactive oxygen species… CONTINUE READING