Acute memory phase of sevoflurane preconditioning is associated with sustained translocation of protein kinase C-alpha and epsilon, but not delta, in isolated guinea pig hearts.

@article{Okusa2009AcuteMP,
  title={Acute memory phase of sevoflurane preconditioning is associated with sustained translocation of protein kinase C-alpha and epsilon, but not delta, in isolated guinea pig hearts.},
  author={Chika Okusa and Masami Miyamae and Shingo Sugioka and Kazuhiro Kaneda and Yoshitaka Inamura and Anna Onishi and Naochika Domae and Junichiro Kotani and Vincent M Figueredo},
  journal={European journal of anaesthesiology},
  year={2009},
  volume={26 7},
  pages={582-8}
}
BACKGROUND AND OBJECTIVE Anaesthetic preconditioning (APC) exerts cardioprotective effects by reducing infarct size and improving recovery of contractile function after ischaemia-reperfusion. The interval between brief exposure to volatile anaesthetic and sustained ischaemia, the acute memory phase, is dependent on intracellular signalling mediating this cardioprotection. Intramyocyte translocation of protein kinase C (PKC) is known to be a key mediator in APC. We examined the relationship… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice.

American journal of physiology. Heart and circulatory physiology • 2004

Similar Papers

Loading similar papers…