Acute megakaryocytic leukemia (M7) in children.

  title={Acute megakaryocytic leukemia (M7) in children.},
  author={Kevin P. Windebank and Ayalew Tefferi and William Anthony Smithson and Chin Yang Li and Lawrence A. Solberg and John R. Priest and Stephen C Elliott and Pedro A de Alarc{\'o}n and Michael E. Weinblatt and E. Omer Burgert},
  journal={Mayo Clinic proceedings},
  volume={64 11},
We analyzed the clinical and laboratory features of eight children (median age, 20 months; range, 13 months to 11 years) with acute megakaryocytic leukemia (M7) and compared the findings with those reported in the literature. The diagnosis was supported by ultrastructural examination for platelet peroxidase or immunophenotyping for glycoprotein IIb/IIIa or the von Willebrand factor protein. Two patients had Down's syndrome. Initial findings included anemia (in all patients), thrombocytopenia… CONTINUE READING

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