Acute megakaryoblastic leukemia without GATA1 mutation after transient myeloproliferative disorder in an infant without Down syndrome.

@article{Inaba2011AcuteML,
  title={Acute megakaryoblastic leukemia without GATA1 mutation after transient myeloproliferative disorder in an infant without Down syndrome.},
  author={Hiroto Inaba and Margherita Londero and Scott H Maurer and Mihaela M Onciu and Yubin Ge and Jeffrey W. Taub and Jeffrey E. Rubnitz and Susana C. Raimondi},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 9},
  pages={e230-3}
}
Case Report A 7-week-old full-term infant girl with unremarkable perinatal history was referred to our hospital for a 5-day history of hematochezia and mild epistaxis. Physical examination showed hepatosplenomegaly, scattered petechiae, and grossly bloody stool. No phenotypic features of Down syndrome (DS) were noted. CBC showed elevated WBC (51.2 10/L) with 10% blasts, anemia (7.1 g/dL), and thrombocytopenia (54 10/L). Bone marrow aspirate (BMA) showed hypercellularity, increased… CONTINUE READING

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