Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.

@article{Hama2008AcuteML,
  title={Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.},
  author={Asahito Hama and Hiroshi Yagasaki and Yoshiyuki Takahashi and Nobuhiro Nishio and Hideki Muramatsu and Nao Yoshida and Makito Tanaka and Hirokazu Hidaka and Nobuhiro Watanabe and Ayami Yoshimi and Kimikazu Matsumoto and Kazuko Kudo and Koji Kato and Keizo Horibe and Seiji Kojima},
  journal={British journal of haematology},
  year={2008},
  volume={140 5},
  pages={552-61}
}
To characterize childhood acute megakaryoblastic leukaemia (AMKL), we reviewed 45 children with AMKL diagnosed between 1986 and 2005 at Nagoya University Hospital and Japanese Red Cross Nagoya First Hospital. Twenty-four patients (53%) had AMKL associated with Down syndrome (DS-AMKL) and 21 (47%) had non-DS-AMKL. The median age of the DS-AMKL patients was 21 months (range, 8-38 months) and that of non-DS-AMKL patients was 15 months (range, 2-185 months). The morphology of blast cells was… CONTINUE READING

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