Acute mechanical hyperalgesia in the rat can be produced by coactivation of spinal ionotropic AMPA and metabotropic glutamate receptors, activation of phospholipase A2 and generation of cyclooxygenase products.

@article{Meller1996AcuteMH,
  title={Acute mechanical hyperalgesia in the rat can be produced by coactivation of spinal ionotropic AMPA and metabotropic glutamate receptors, activation of phospholipase A2 and generation of cyclooxygenase products.},
  author={Stephen Trevor Meller and Claude L. Dykstra and Gerald F. Gebhart},
  journal={Progress in brain research},
  year={1996},
  volume={110},
  pages={
          177-92
        }
}
Publisher Summary This chapter focuses on the characterization of the glutamate receptor subtypes and the signal transduction mechanisms that are involved in acute mechanical hyperalgesia. It discusses the results obtained from the experiment that acute mechanical hyperalgesia can be produced by coactivation of spinal ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) and metabotropic glutamate receptor subtypes, activation of PLA, and production of cyclooxygenase (COX… CONTINUE READING

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