Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex

@article{Michael2003AcuteMI,
  title={Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex},
  author={N. Michael and A. Erfurth and P. Ohrmann and Michael G{\"o}ssling and V. Arolt and W. Heindel and B. Pfleiderer},
  journal={Psychopharmacology},
  year={2003},
  volume={168},
  pages={344-346}
}
RationaleThe dorsolateral prefrontal cortex (DLPFC) participates in the pathophysiology of mania. In particular, left-sided structural and metabolic abnormalities have been described.ObjectivesClinical symptoms may be due to hyperactivity of cortical glutamatergic neurons, resulting in increased excitatory neurotransmitter flux and thus enhanced Glx levels.MethodsGlutamate/glutamine (Glx) levels were assessed by proton magnetic resonance spectroscopy (1H-MRS) in eight acute manic patients… Expand
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