Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex

@article{Michael2003AcuteMI,
  title={Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex},
  author={N. Michael and A. Erfurth and P. Ohrmann and Michael G{\"o}ssling and V. Arolt and W. Heindel and B. Pfleiderer},
  journal={Psychopharmacology},
  year={2003},
  volume={168},
  pages={344-346}
}
  • N. Michael, A. Erfurth, +4 authors B. Pfleiderer
  • Published 2003
  • Medicine, Psychology
  • Psychopharmacology
  • RationaleThe dorsolateral prefrontal cortex (DLPFC) participates in the pathophysiology of mania. In particular, left-sided structural and metabolic abnormalities have been described.ObjectivesClinical symptoms may be due to hyperactivity of cortical glutamatergic neurons, resulting in increased excitatory neurotransmitter flux and thus enhanced Glx levels.MethodsGlutamate/glutamine (Glx) levels were assessed by proton magnetic resonance spectroscopy (1H-MRS) in eight acute manic patients… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The proposed 3-week, double-blind, crossover, proof of concept study aims to manipulate neurochemical dysfunctions characteristic of individuals with co-occurring BD and AUD (i.e… Expand
    ConditionsAlcohol Use Disorder, Bipolar Disorder
    InterventionDrug
    Elevated metabolites within dorsolateral prefrontal cortex in rapid cycling bipolar disorder
    • 29
    Bipolar mania and plasma amino acids: Increased levels of glycine
    • 38
    Increased Anterior Cingulate/Medial Prefrontal Cortical Glutamate and Creatine in Bipolar Depression
    • 168
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 26 REFERENCES
    Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study
    • 469
    • Highly Influential
    Subgenual prefrontal cortex abnormalities in mood disorders
    • 2,396
    A neuropsychological investigation of prefrontal cortex involvement in acute mania.
    • 264
    Frontosubcortical neuroanatomy and the continuous performance test in mania.
    • 226