Acute lymphoblastic leukaemia

  title={Acute lymphoblastic leukaemia},
  author={Hiroto Inaba and Mel Greaves and Charles G Mullighan},
  journal={The Lancet},
Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous exposures, genetic susceptibility, and chance have roles. Survival in paediatric acute lymphoblastic leukaemia has improved to roughly 90% in trials with risk stratification by biological features of leukaemic cells and response to treatment, treatment modification based on patients' pharmacodynamics and pharmacogenomics… CONTINUE READING
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