Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normo- and spontaneously hypertensive rats.

@article{Kodavanti2001AcuteLI,
  title={Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normo- and spontaneously hypertensive rats.},
  author={Urmila P Kodavanti and Mette C.J. Schladweiler and Judy R Richards and Daniel L. Costa},
  journal={Inhalation toxicology},
  year={2001},
  volume={13 1},
  pages={37-54}
}
We have recently shown that the spontaneously hypertensive (SH) rats with underlying cardiovascular disease exhibited greater pulmonary vascular leakage and oxidative stress than healthy normotensive (Wistar Kyoto, WKY) rats after a 3-day inhalation exposure to residual oil fly ash (ROFA) particles (Kodavanti et al., 2000). Since host responsiveness to a 3-day episodic ROFA inhalation could be different from a single acute exposure, we examined ROFA and its constituent metal (vanadium, V… CONTINUE READING
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