Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), characterized by an excessive inflammatory response involving a variety of inflammatory mediators, are associated with high morbidity and mortality in intensive care medicine

Abstract

Acute lung injury (ALI) remains one of major causes of morbidity and mortality in intensive care medicine. The lack of efficient pharmacological interventions contributes to the high mortality rate of ALI. Losartan, an antagonist of angiotensin II (Ang II) type 1 receptor, is a potent therapeutic drug for ALI. Recent reports suggest that losartan inhibits… (More)

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