Acute loss of TET function results in aggressive myeloid cancer in mice

  title={Acute loss of TET function results in aggressive myeloid cancer in mice},
  author={Jungeun An and Edah{\'i} Gonz{\'a}lez-Avalos and Ashu Chawla and Mira Jeong and Isaac F. L{\'o}pez-Moyado and Wei Li and Margaret A. Goodell and Lukas Chavez and Myunggon Ko and Anjana Rao},
  booktitle={Nature communications},
TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukaemia in mice, pointing to a causative role for TET loss-of-function in this myeloid malignancy. Phenotypic and… CONTINUE READING
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Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

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  • Nature 523,
  • 2015

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