Acute liver failure is regulated by MYC- and microbiome-dependent programs

@article{Kolodziejczyk2020AcuteLF,
  title={Acute liver failure is regulated by MYC- and microbiome-dependent programs},
  author={Aleksandra A. Kolodziejczyk and Sara Federici and Niv Zmora and Gayatree Mohapatra and Mally Dori-Bachash and Shanni Hornstein and Avner Leshem and Debby Reuveni and Ehud Zigmond and Ana Tobar and Tomer Meir Salame and Alon Harmelin and Amir Shlomai and Hagit Shapiro and Ido Amit and Eran Elinav},
  journal={Nature Medicine},
  year={2020},
  volume={26},
  pages={1899-1911}
}
Acute liver failure (ALF) is a fulminant complication of multiple etiologies, characterized by rapid hepatic destruction, multi-organ failure and mortality. ALF treatment is mainly limited to supportive care and liver transplantation. Here we utilize the acetaminophen (APAP) and thioacetamide (TAA) ALF models in characterizing 56,527 single-cell transcriptomes to define the mouse ALF cellular atlas. We demonstrate that unique, previously uncharacterized stellate cell, endothelial cell, Kupffer… 
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