Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation.

Abstract

Patients with mutations in the POLG1 gene encoding mitochondrial DNA polymerase gamma have an increased risk of valproate-induced liver failure. POLG1 mutations are common, and these patients often suffer from intractable seizures. The role of liver transplantation in the treatment of patients with mitochondrial diseases has been controversial. We studied… (More)
DOI: 10.1002/lt.23965

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