Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteria

@article{Shakil2000AcuteLF,
  title={Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteria},
  author={A. Obaid Shakil and David J. Kramer and George V Mazariegos and John J Fung and Jorge Rakela},
  journal={Liver Transplantation},
  year={2000},
  volume={6}
}
Acute liver failure(ALF)is an uncommon condition associated with high morbidity and mortality. We performed a retrospective analysis of patients evaluated for ALF. The aim of our study is to determine the clinical features and outcome of such patients and to assess the validity of King's College Hospital (KCH) prognostic criteria. One hundred seventy‐seven patients were evaluated for ALF during a period of 13 years. Mean age was 39 years, and 63% were women. The causes included viral hepatitis… 
Changing etiologies and outcomes of acute liver failure: Perspectives from 6 transplant centers in Argentina
  • M. Mendizabal, S. Marciano, +10 authors M. Silva
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2014
TLDR
Hepatitis B and AIH were the most frequent causes of fulminant hepatic failure in Argentina, and no cases of ACM overdosing were identified.
Aetiology and outcome of acute liver failure.
TLDR
Liver transplantation, when performed for acute liver failure, has good long-term survival and paracetamol overdose was the most common cause of acute Liver failure.
Early indicators of prognosis in fulminant hepatic failure: An assessment of the Model for End‐Stage Liver Disease (MELD) and King's College Hospital Criteria
  • R. Dhiman, Sanjay Jain, +5 authors Y. Chawla
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2007
TLDR
In conclusion, MELD and KCH criteria are not as useful as a combination of other early CPI in predicting adverse outcome in patients with FHF due to acute viral hepatitis.
Prognostic value of model for end-stage liver disease scores in patients with fulminant hepatic failure.
TLDR
The findings of this study suggest that patients with fulminant hepatic failure may need emergent LT for survival, and a MELD score ≥30 was found to be the only independent risk factor of mortality in FHF patients without LT.
Liver Failure: Acute and Acute on Chronic
Acute liver failure (ALF) is defined as the development of hepatic encephalopathy (HE) and coagulopathy in a patient with no history of previous liver disease, with the onset HE within 26 weeks of
Aetiology, Clinical Profiles, Laboratory Profile, Outcome and Prognostic Factors of Pediatric Acute Liver Failure: Experience at a Tertiary Hospital of Bangladesh
TLDR
Ascites, high total bilirubin, high INR and etiology like Wilson disease were the worse pronostic factors for outcome of acute liver failure in children.
Comparison of the Applicability of Two Prognostic Scoring Systems In Patients with Fulminant Hepatic Failure
TLDR
The London criteria more accurately predicted the need for transplantation, and neither the London criteria nor the Clichy prognostic criteria accurate predicted the outcome of those patients who suffered with FHF due to ACM.
Phosphorus ans an early predictive factor in patients with acute liver failure1
TLDR
Hypophosphatemia and early phosphorus administration are associated with a good prognosis in ALF, whereas hyperphosphatemicemia is predictive of poor recovery.
Development of an accurate index for predicting outcomes of patients with acute liver failure.
TLDR
The ALFSG index, a combination of clinical markers and measurements of the apoptosis biomarker M30, better predicts outcomes of patients with ALF than the KCC or MELD.
Fulminant Hepatic Failure and the Potential Role of Liver Dialysis
TLDR
This study confirmed that the diagnosis of non-acetaminophen induced FHF and reduced initial serum factor V level are associated with fatal outcome and timely OLT significantly improved the survival.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Etiology and outcome for 295 patients with acute liver failure in the United States.
  • F. V. Schiødt, E. Atillasoy, +11 authors W. M. Lee
  • Medicine
    Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 1999
TLDR
Age did not differ between survivors and nonsurvivors, perhaps reflecting a selection bias for patients transferred to liver transplant centers, but showed a trend toward affecting both survival and transplantation rate.
Early indicators of prognosis in fulminant hepatic failure: an assessment of the King's criteria.
TLDR
The King's College Hospital criteria for predicting outcome of fulminant hepatic failure were found to have a slightly lower predictive accuracy than shown in the original study.
Emergency liver transplantation for acute liver failure. Evaluation of London and Clichy criteria.
TLDR
Two sets of prognostic indicators were recently proposed for selection of patients with acute liver failure for emergency liver transplantation and the positive predictive values were equal to 1 for the two sets, but the predictive accuracies only slightly increased.
Liver transplantation for acute liver failure: analysis of applicability.
TLDR
Considering the high survival rate obtained in the patients with transplantations and the poor survival rate observed in those who could not be transplanted, efforts should be made to increase liver transplant applicability to improve the prognosis in acute liver failure.
Liver transplantation for fulminant hepatic failure.
TLDR
Actuarial patient and graft survival for FHF and SHF were assessed and compared with the outcome for all patients who underwent liver transplantation at the same center over the same period and rapid assessment of candidacy and aggressive treatment for intracranial hypertension were thought to be essential in the outcome.
The role of transjugular liver biopsy in fulminant liver failure: Relation to other prognostic indicators
TLDR
Results indicate that transjugular liver biopsy is both safe and effective as an adjuvant to the King's College criteria in the diagnosis and prognosis of patients with nonacetaminophen‐induced fulminant liver failure.
Histopathological heterogeneity in fulminant hepatic failure
TLDR
The approach to the patient with fulminant hepatic failure should be guided principally on clinical grounds, and further classification should be based on pathological and etiologic considerations, however, histological classification and prognosis based on percutaneous biopsy specimens alone may be misleading.
Acute liver failure: redefining the syndromes
TLDR
Hyperacute liver failure is the authors' suggested term for cases in which encephalopathy occurs within 7 days of the onset of jaundice; this group includes the sizeable cohort likely to survive with medical management despite the high incidence of cerebral oedema.
Early indicators of prognosis in fulminant hepatic failure.
The successful use of orthotopic liver transplantation in fulminant hepatic failure has created a need for early prognostic indicators to select the patients most likely to benefit at a time when
Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage.
TLDR
Observations suggest that many patients presently dying from fulminant hepatic failure may be expected to survive, once more effective therapy is available for the complications of the illness.
...
1
2
3
4
...