Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes.

@article{Medts2010AcuteLS,
  title={Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes.},
  author={Thierry Medts and Philippe de Diesbach and Antoine Cominelli and Francisca N'kuli and Donatienne Tyteca and Pierre J. Courtoy},
  journal={Experimental cell research},
  year={2010},
  volume={316 19},
  pages={3239-53}
}
Src, a non-receptor tyrosine kinase, is a key signal transduction partner of epidermal growth factor (EGF) receptor (EGFR). In human breast cancer, EGFR and Src are frequently over-expressed and/or over-activated. Although reciprocal activation is documented, mechanisms underlying Src:EGFR interactions are incompletely understood. We here exploited ts/v-Src thermo-activation in MDCK monolayers to test whether acute Src activation impacts on signalling and trafficking of non-liganded EGFR. We… CONTINUE READING

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