Acute leukemia with myeloid, B-, and natural killer cell differentiation.


Biphenotypic acute leukemias account for 4% to 8% of all acute leukemias. Most of these leukemias are of myeloid-B-cell or myeloid-T-cell lineage. Acute myeloid-natural killer cell leukemia has been recognized recently. We report the first case, to our knowledge, of CD56(+) acute leukemia showing unequivocal myeloid and B-cell differentiation in a 20-year-old woman, whose blast cells were positive for myeloperoxidase, CD13, CD33, CD117, terminal deoxynucleotidyl transferase, CD19, CD20, CD22, CD34, HLA-DR, and CD56 but negative for CD3, CD5, CD7, and CD10. Rare Auer rods were identified in the blast cells. Polymerase chain reaction assays showed rearrangement of immunoglobulin heavy-chain gene and absence of Epstein-Barr virus DNA. We propose that this novel form of multilineage leukemia may represent the neoplastic counterpart of a progenitor that can give rise to myeloid, B, and natural killer cells.


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@article{Lee2003AcuteLW, title={Acute leukemia with myeloid, B-, and natural killer cell differentiation.}, author={Po-Shing Lee and Ching-Nan Lin and Chientzu Liu and Chien-Tai Huang and Wei-Shiou Hwang}, journal={Archives of pathology & laboratory medicine}, year={2003}, volume={127 2}, pages={E93-5} }