Acute leukemia in early childhood.

  title={Acute leukemia in early childhood.},
  author={Mariana Emerenciano and S{\'e}rgio Koifman and Maria S Pombo-de-Oliveira},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  volume={40 6},
Acute leukemia in early childhood is biologically and clinically distinct. The particular characteristics of this malignancy diagnosed during the first months of life have provided remarkable insights into the etiology of the disease. The pro-B, CD10 negative immunophenotype is typically found in infant acute leukemia, and the most common genetic alterations are the rearrangements of the MLL gene. In addition, the TEL/AML1 fusion gene is most frequently found in children older than 24 months. A… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms

International journal of molecular sciences • 2016
View 6 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 62 references

The MLL recombinome of acute leukemias

Leukemia • 2006
View 4 Excerpts
Highly Influenced

Maternal diet and infant leukemia: a role for DNA topoisomerase II inhibitors?

International journal of cancer. Supplement = Journal international du cancer. Supplement • 1998
View 4 Excerpts
Highly Influenced

Infant leukaemia biology, aetiology and treatment.

Leukemia • 1996
View 5 Excerpts
Highly Influenced

Infant acute leukemia and maternal exposures during pregnancy.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…