Acute leukemia in early childhood.

@article{Emerenciano2007AcuteLI,
  title={Acute leukemia in early childhood.},
  author={Mariana Emerenciano and S{\'e}rgio Koifman and Maria S Pombo-de-Oliveira},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2007},
  volume={40 6},
  pages={749-60}
}
Acute leukemia in early childhood is biologically and clinically distinct. The particular characteristics of this malignancy diagnosed during the first months of life have provided remarkable insights into the etiology of the disease. The pro-B, CD10 negative immunophenotype is typically found in infant acute leukemia, and the most common genetic alterations are the rearrangements of the MLL gene. In addition, the TEL/AML1 fusion gene is most frequently found in children older than 24 months. A… CONTINUE READING

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