Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam

  title={Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam},
  author={Tausif Zar and Irfan Yusufzai and Anna M. Sullivan and Charles Graeber},
  journal={Nature Clinical Practice Nephrology},
Background A 54-year-old male with a history of multiple admissions for alcohol intoxication was admitted to hospital with right flank pain. He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap metabolic acidosis, and acute kidney injury on his eighth day of hospitalization.Investigations Serum chemistries, arterial blood gas analysis, and measurement of serum propylene glycol, ethylene glycol and methanol… CONTINUE READING


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