Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis.

  title={Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis.},
  author={Joris R. de Groot and Ruben Coronel},
  journal={Cardiovascular research},
  volume={62 2},
Sudden cardiac death forms a major cause of mortality. Myocardial ischemia-induced ventricular fibrillation (VF) is frequently the underlying mechanism. Ventricular arrhythmias arise in two distinct phases during the first hour of ischemia. The first, the 1A phase, has been extensively studied, and few studies relate to the 1B phase. The latter is associated with intercellular electrical uncoupling, mediated by decreased conductance of gap junction channels. Although the relation between gap… CONTINUE READING