Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice.

@article{Burcelin1999AcuteIL,
  title={Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice.},
  author={R{\'e}mi Burcelin and Seika Kamohara and Jing Li and Gloria Shaffer Tannenbaum and Maureen J. Charron and Jeffrey M. Friedman},
  journal={Diabetes},
  year={1999},
  volume={48 6},
  pages={1264-9}
}
The mouse ob gene encodes leptin, an adipocyte hormone that regulates body weight and energy expenditure. Leptin has potent metabolic effects on fat and glucose metabolism. A mutation of the ob gene results in mice with severe hereditary obesity and diabetes that can be corrected by treatment with the hormone. In lean mice, leptin acutely increases glucose metabolism in an insulin-independent manner, which could account, at least in part, for some of the antidiabetic effect of the hormone. To… CONTINUE READING

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