Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation.

@article{Baker2008AcuteIO,
  title={Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation.},
  author={Susan M Baker and Namho Kim and Anna M. Gumpert and Dominique Segretain and Matthias M Falk},
  journal={FEBS letters},
  year={2008},
  volume={582 29},
  pages={4039-46}
}
During the inflammatory response, activation of G-protein coupled receptors (GPCRs) by inflammatory mediators rapidly leads to inhibition of gap junction intercellular communication (GJIC); however, the steps that lead to this inhibition are not known. Combining high-resolution fluorescence microscopy and functional assays, we found that activation of the GPCRs PAR-1 and ET(A/B) by their natural inflammatory mediator agonists, thrombin and endothelin-1, resulted in rapid and acute… CONTINUE READING