Acute inotropic and lusitropic effects of cardiomyopathic R9C mutation of phospholamban.

@article{Abrol2015AcuteIA,
  title={Acute inotropic and lusitropic effects of cardiomyopathic R9C mutation of phospholamban.},
  author={Neha Abrol and Pieter P. de Tombe and Seth L Robia},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 11},
  pages={7130-40}
}
A naturally occurring R9C mutation of phospholamban (PLB) triggers cardiomyopathy and premature death by altering regulation of sarco/endoplasmic reticulum calcium-ATPase (SERCA). The goal of this study was to investigate the acute physiological consequences of the R9C-PLB mutation on cardiomyocyte calcium kinetics and contractility. We measured the physiological consequences of R9C-PLB mutation on calcium transients and sarcomere shortening in adult cardiomyocytes. In contrast to studies of… CONTINUE READING