Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats.

@article{Roy2011AcuteIO,
  title={Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats.},
  author={Christian Roy and Marie-Claude Roy and Danny Gauvreau and Anne-Marie Poulin and Fun-Qun Tom and Elena Timofeeva and Denis Richard and Katherine Cianflone},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={301 1},
  pages={E232-41}
}
Acylation-stimulating protein (ASP; also known as C3adesArg) stimulates triglyceride synthesis and glucose transport via interaction with its receptor C5L2, which is expressed peripherally (adipose tissue, muscle) and centrally. Previous studies have shown that ASP-deficient mice (C3KO) and C5L2-deficient mice (C5L2KO) are hyperphagic (59 to 229% increase, P < 0.0001), which is counterbalanced by increased energy expenditure measured as oxygen consumption (Vo(2)) and a lower RQ. The aim of the… CONTINUE READING