Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells.

@article{Kempson2008AcuteIO,
  title={Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells.},
  author={Stephen A. Kempson and Jason Matthew Edwards and Alyssa Osborn and Michael Stephen Sturek},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={295 1},
  pages={
          F108-17
        }
}
Extracellular ATP interacts with purinergic P2 receptors to regulate a range of physiological responses, including downregulation of transport activity in the nephron. ATP is released from cells by mechanical stimuli such as cell volume changes, and autocrine signaling by extracellular ATP could occur in renal medullary cells during diuresis. This was tested in Madin-Darby canine kidney (MDCK) cells, a model used frequently to study P1 and P2 receptor activity. ATP was released within 1 min… CONTINUE READING

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