Acute inhibition of corticosteroidogenesis by inhibitors of calmodulin action.

@article{Carsia1982AcuteIO,
  title={Acute inhibition of corticosteroidogenesis by inhibitors of calmodulin action.},
  author={Rocco V. Carsia and William R. Moyle and Donald J Wolff and Sasha Malamed},
  journal={Endocrinology},
  year={1982},
  volume={111 5},
  pages={1456-61}
}
To identify the possible role of calmodulin in ACTH function, we tested the ability of chlorpromazine (CP) and other calmodulin antagonists to inhibit steroidogenesis of isolated adrenocortical cells of the rat. CP reversibly inhibited maximal ACTH-induced corticosterone (B) production. The presence of the drug did not alter the ED50 of ACTH stimulation (3… CONTINUE READING