Acute inhalation of 2,2,4-trimethylpentane alters visual evoked potentials and signal detection behavior in rats.

@article{Boyes2010AcuteIO,
  title={Acute inhalation of 2,2,4-trimethylpentane alters visual evoked potentials and signal detection behavior in rats.},
  author={William K Boyes and Wendy M. Oshiro and Hisham A. El-Masri and Laura L. Degn and Mark Bercegeay and Quentin Todd Krantz and Philip J. Bushnell},
  journal={Neurotoxicology and teratology},
  year={2010},
  volume={32 5},
  pages={525-35}
}
The volatile organic compound 2,2,4-trimethylpentane (TMP, "isooctane") is a constituent of gasoline for which the current health effects data are insufficient to permit the US Environmental Protection Agency to conduct a risk assessment. The potential neurological impairment from acute inhalation exposure to TMP was evaluated in adult male Long-Evans rats using both electrophysiological and behavioral assessments. Visual evoked potentials (VEPs) were recorded from rats viewing modulated visual… CONTINUE READING